صفحات سایت / گروه اصلی

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Zebrafish Core Facility

Animals represent numerous human physiological and pathological processes and are central component of experiments to investigate mechanisms of human diseases and effective therapies.

Animals are also applied in studies where using human subjects seems inaccessible. In the past, mammals and rodents have been used habitually for modelling of human diseases.

However, experimental zebrafish animal model is expeditiously receiving acceptance by the scientists. In scientific researches, we often use zebrafish (Danio rerio), a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.

With its more than 70 percent genetic similarity to human, zebrafish is currently considered as an important and widely used experimental vertebrate model in genetic disorders, drug developments, and pre-clinical studies.

The perfect mimicry potential of inflammatory processes has made zebrafish to be considered as an excellent model to study non communicable diseases(NCD) as diabetes, osteoporosis, metabolic disorders, and cancers.

To address this need, based on an approved proposal, Professor Larijani, the President of EMRI chartered and authorized Prof. M.Reza Khorramizadeh, Director of Biosensor Research Center to establish and conduct an experimental zebrafish lab at EMRI.

He arranged a technical squad as follows: Dr. Fatemeh Bootorabi, a graduate from Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Dr. Hamed Manouchehri and Dr. Reza Changizi, assistant professors from Department of Aquaculture Science, Babol Branch, Islamic Azad University, Babol, Iran;  Hasan Mohammadi, a PhD student in fish reproduction and breeding.

With his professional team, Prof. Khorramizadeh set out to achieve the lab-establishment objectives. Within two years, the zebrafish lab setup project was completed and now, regulated by EMRI and TUMS ethical committee, is operating with ongoing research projects. The established zebrafish lab has been missioned to be an EMRI core facility for NCD animal modelling experiments.

Upon communication and introduction of the lab and its potentials, it has joined to Zebrafish International Network, ZFIN.org, and registered as Zebrafish Core Facility – EMRI (ZFIN ID: ZDB-LAB-190117-2) for upcoming research endeavors.